At the end of the 1940s, Cairoli met Torres Garcia who sparked his interest in the theories of Constructivism and the art of Piet Mondrian. Cairoli became particularly interested in the effects of light on material and joined a group with Lucio Fontana involving in spatial research. Cairoli moved to Paris in 1952 where he worked on complex plexiglass sculptures and participated in Groupe Espace exhibitions. This group, following the lead of De Stijl, was dedicated to the neo-plastic ideal of synthesizing all the visual arts within architectural space. Cairoli endeavored to explore the virtues of transparency through spatial constructions using Plexiglas. In Structure Spatiale orthogonale (1956–57), Cairoli stratifies the space by placing one transparent, vertical structure which is subtly emphasized by the shadow it throws. This work, remarkable for its sophistication and quality of execution, fully embodies the work of Cairoli in the wake of early Constructivist artists.